| Computer pioneer Lovelace (woo-hoo, women in tech!) |
| Autosuggestion pioneer: 1857–1926 |
| Electric guitar pioneer Fender |
| Pioneering underground publication of the 1960s |
| AncestryDNA enclosure |
| Ambient pioneer Brian |
| Photography pioneer Louis |
| Pioneering child care author |
| Ambient music pioneer who composed the "Microsoft Sound" for Windows 95: 2 wds. |
| Pharmaceutical pioneer Lilly |
| Aspirin pioneer Hoffmann |
| Abstract art pioneer Jean |
| Massage therapy pioneer Ida |
| Automobile pioneer Gottlieb |
| Agricultural pioneer |
| DNA strand's shape |
| Pioneering web portal |
| Ambient music pioneer |
| Edna's edibles |
| Pioneer 10 or Voyager 1 |
| Antiseptic surgery pioneer |
| Computing pioneer Lovelace |
| Genre pioneered by Miles Davis |
| French auto pioneer |
| Echidna's edibles |
| Inventor and electricity pioneer (the coil named for him is twisted up in four answers) |
| Actress who played Edna Garrett on "Diff'rent Strokes" and "The Facts of Life |
| A missile, not a game show pioneer |
| Abrasive composed of silicon carbide — our DNA crumb (anag) |
| Optical products pioneer |