| Artist |
| Lefty artist |
| Rome airport |
| Renaissance man |
| St. Jerome" painter |
| Rome airport eponym |
| La Gioconda" painter |
| The Last Supper" artist |
| Proto-helicopter designer |
| All-around guy from Tuscany |
| St. John the Baptist" painter |
| Creator of an enigmatic smile |
| Creator of the Codex Leicester |
| Artist whose last name is a code |
| The dude known for a famous supper |
| He made the Mona Lisa smile: 3 wds. |
| Multitalented subject of this puzzle |
| Great pioneer in science (1452–1519). |
| Famed protégé of Lorenzo the Magnificent |